Msemo
(aphorism)
Mzumbua
kijungu ndiye mpishi.
Literal:
The person who brought forth the small cooking pot is the cook.
A
person who started the lies implicating somebody is the one who did it in the
first place.
For
example, in a situation where a group of people had prepared a feast and
brought the collectively invested and guarded big cooking pot, but suddenly
that big cooking pot got ostensibly lost. The person who starts lying and
accusing others and brings out his own small cooking pot as a supposed “solution”
is the one who knows how the big cooking pot was stolen and hidden. The small
cooking pot is obviously incapable of catering to the entire group. This is analogous
to a situation where a group of people are in a state of confoundment and shock
after a given event. In such a situation, the person who starts vehemently hurling
accusations and trying to implicate others in the group is the one who knows
how the whole event was planned.
A
character that does this takes advantage of the association of confoundment with
bias. For example, the accusations will most likely be directed towards the
owner of the house where the big cooking pot was temporarily stored.
Zumbua – 1. subsist, maintain. 2. start.
Kijungu (dimunitive of ‘nyungu’) nyungu - clay pot.
Kijungujiko - subsistence.
Confounding
and bias
The
importance of confounding is that it suggests an association where none exists
or masks a true association.
In
research studies, ‘exposure’ refers to so-called independent variables while ‘outcome’
refers to so-called dependent variables. A large proportion of research studies
assess the relationship between two variables. Here, the question is whether
one variable is associated with or responsible for change in the value of the
other variable.
Exposures
(independent variables)
Exposure
variables can either be naturally determined (like age, sex, time, temperature,
pressure, genetics) or socioeconomically determined (like smoking, educational
status, political position, drug use). The socioeconomically-determined
variables are termed ‘exposure’ if they are a considered variable before the study,
and are considered ‘intervention’ if they are introduced to the subjects for
the purpose of the study. For example, if
a drug’s use had been started in all the subjects or in some subjects but not
in the others, before the study started, this counts as ‘exposure’, and not as
intervention – since the drug was not started specifically for the study, and
this may be a potential source of confounding in results if not considered. However,
if the drug is newly introduced to all the subjects for the purpose of the
study, this counts as ‘intervention’.
Intervention
is normally done in experimental studies while exposure is normally considered
in observational studies. Observational studies are those where the researcher
is documenting a naturally occurring relationship between the exposure and the
outcome that he/she is studying. The researcher does not do any active
intervention in any subject, and the exposure has already been decided
naturally or by some other factor out of the researcher’s control. Experimental
studies on the other hand are studies where the researcher actively performs an
intervention in some or all subjects. This intervention could take many forms –
for example, administration of a drug, introduction of a chemical catalyst,
introduction of a chemical inhibitor, layering, performance of a diagnostic or
therapeutic procedure, introduction of an educational tool and so forth.
Outcomes
(dependent variables)
The
outcome (or predicted or dependent) variable develops as a consequence of the
exposure (or intervention). Outcomes are the events or endpoints that are
monitored during a study to document the impact that a given intervention or
exposure has on the “characteristics of study” of the subject. The purpose of
outcomes is to be used as a tool to provide evidence about benefits, risks, and
results of exposures and interventions so that individuals can make more
informed decisions. Outcomes desired can be economic, clinical (comparative
clinical effectiveness), sociopolitical, structural, efficiency (time-related),
productivity (energy, longevity) or humanistic (quality-of-life-related), and
so forth depending on area of study. For example, one may want an outcome of
batteries that store a high amount of energy and release only required amounts
over a long period of time while undergoing minimal degradation.
Confoundment
Confounding
is a distortion that modifies an association between an exposure and an outcome
because a factor is independently associated with the exposure and the outcome.
Confounding of variables commonly occurs in observational studies, but can also
occur in experimental studies, especially, but not only, if they are poorly
designed. For example, if by chance more elderly people are experimented with
an active intervention than to placebo, and if age is independently more likely
to be associated with a beneficial outcome, the intervention may falsely appear
to be beneficial. In this example, the distortion arises from the unbalanced exposure
(age) to the outcome (effectiveness) because the probability of bias in results
was not reduced through deliberate balancing of the elderly subjects in equal
number on the active intervention side and on the placebo side, with a similar balancing
for the younger subjects to see the difference. The deliberate balancing of the
age exposure variable on both the active intervention and placebo may give more
accurate outcomes that diminish confoundment because it will be observed that
the intervention is more effective in the elderly sample.
Another
way of confoundment is the introduction of an unproven concept that seems
logically compelling, to explain an observation. An example is the concept of ‘allelopathy’.
This is a concept of a biological phenomenon by which an organism produces one
or more biochemicals that influence the germination, growth, survival, and
reproduction of other organisms. The supposed biochemicals are termed ‘allelochemicals’.
As a result of the introduction of this unproven but logically compelling
concept, it can often be difficult in practice to distinguish allelopathy from
resource competition. While the former is supposed to be caused by the addition
of a harmful chemical agent to the environment, the latter is caused by the
removal of essential nutrients (or water). Often, both mechanisms can be deemed
to act simultaneously. Moreover, some allelochemicals are said to function by
reducing nutrient availability. Further confounding the issue, the production
of allelochemicals can itself be affected by environmental factors such as
nutrient availability, temperature and pH.
The
term allelopathy was first used in 1937 by the Austrian professor Hans Molisch
in the book Der Einfluss einer Pflanze auf die andere - Allelopathie (The
Effect of Plants on Each Other - Allelopathy) published in German. He used the
term to describe “biochemical interactions by means of which a plant inhibits
the growth of neighbouring plants”. In 1971, Whittaker and Feeny published a
review in the journal Science, which proposed an expanded definition of
allelochemical interactions that would incorporate all chemical interactions
among organisms. In 1984, Elroy Leon Rice in his monograph on allelopathy
enlarged the definition to include all direct positive or negative effects of a
plant on another plant or on micro-organisms by the “liberation of biochemicals”
into the natural environment. Over the next ten years, the term was used by
other researchers to describe broader chemical interactions between organisms,
and by 1996 the International Allelopathy Society (IAS) defined allelopathy as
"Any process involving secondary metabolites produced by plants, algae,
bacteria and fungi that influences the growth and development of agriculture
and biological systems". In more recent times, plant researchers have
begun to switch back to the original definition of substances that are produced
by one plant that inhibit another plant. Confusing the issue more, zoologists
have borrowed the term to describe chemical interactions between invertebrates
like corals and sponges.
Allelopathy,
just like homeopathy, seems to be inspired by the pseudoscientific concept of animal
magnetism/mesmerism invented by German doctor Franz Mesmer in the 18th century.
It posits the existence of an invisible natural force possessed by all living
things, including humans, animals, and vegetables, which could have physical
effects, including healing. Unwarranted injection of unproven concepts into observations,
is a form of superstition that leads to confoundment.
References
Aronson JK, Bankhead C, Nunan
D. Confounding (2018). Catalogue of bias collaboration, In Catalogue Of Biases.
www.catalogueofbiases.org/biases/confounding
Mohamed Said Ahmed (1974).
Vito Vya Hekima, Simo Na Maneno Ya Mshangao. Nairobi: Longman.
Ranganathan, P., &
Aggarwal, R. (2018). Study designs: Part 1 - An overview and classification. Perspectives
in clinical research, 9(4), 184–186.
TUKI (2001), Kamusi Ya
Kiswahili-Kiingereza; Swahili-English Dictionary. Published by Taasisi ya
Uchunguzi wa Kiswahili (TUKI), Chuo Kikuu cha Dar es Salaam, Tanzania.
Willis, Rick J. (2007). The
History of Allelopathy. Springer.
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