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Poromoka - glide or slip down in a mass,
cascade.
-poromoka (infinitive kuporomoka)
1.
to slide, to slip, to cascade
Nominal
derivations:
Poromoko (“landslide, avalanche, steep drop”). -
conceptual
Maporomoko – cascade/fall debris – object
“Let
the chips fall where they may” is an idiom that means to be satisfied with the
results of something. The phrase is usually used when one is doing everything
one can to achieve a certain outcome, but at a certain point, the outcome is
out of one's hands and whatever will happen, will happen.
There
is a simple sequential way of converting nitrogen into ammonia called the
Haber-Bosch process, used to create fertiliser. The process however requires a
lot of energy(heat) to carry out. Bacteria on the other hand do it at room
temperature but scientists don’t understand the core dynamics of it because
it’s too complicated. Therefore, there is a lot of energy being expended in the
world to understand how complex sequential processes are effected with so
little energy by natural processes. This is the core idea and motivation behind
fields of: quantum computing, artificial intelligence, and crispr cascades genetic
engineering and “vaccines”. The word vaccines is in quotations because the idea
of vaccines involves inoculation with a weakened pathogen to stimulate heightened
immune activity that will prevent infection. Crispr cascades “vaccines” on the
other hand work by genetically engineering genes in a person/animal/plant by
initiating a sequence of cleavages/slicings on the genetic strands of the DNA
that get entangled. The aim is destroying certain genetic information as a
method of preventing viral infection. The conjured mass worldwide experiment using
“covid vaccines” showed that all of them were ineffective as far as covid
prevention is concerned, as exhibited by infections after multiple “vaccinations”.
Other effects of the genetic engineering is probably still a point of debate
and observation.
To
illustrate this process using biological terms, a CRISPR-associated complex for
antiviral defense in GMO plants, (Cascade)15, comprised of 3–5 proteins
(depending on the subtype), facilitates RNA-guided DNA target recognition. Once
in entanglement with the target, a processive single stranded enzyme, Cas3, is
recruited to and activated by the Cascade complex to perform target DNA
destruction.
These
seemingly varied fields are for the purpose of creating a model/framework for
understanding natural cascades and how to predict and control them.
Understanding cascades in quantum computing is being hoped to help in modelling
environmental, social and political cascades so as to control important points
of action and consequently, the outcome. For example, if a Eurasian nation
desires to invade another nation, it may use quantum computing models to
identify important points of activity and how to control the outcome of the war.
Another example is, if a Eurasian nation imposes economic sanctions on other
nations, it would use the “quantum” model to identify important points of
activity to manipulate and make the sanctions more effective. Despite restrictions and cartelization, the processes of
war or economy are very complex hence the outcomes are generally by chance, that’s
why economic sanctions against Zimbabwe, Russia, Iran, Venezuela and others
have generally failed. Similarly, despite Russia and Ukraine being coerced into
war, the desired outcomes by the instigators have generally failed. The
outcomes of WW1 and WW2 was the general end of colonial occupation, which was
an outcome that the instigators of the wars still regret till today as was
clearly expressed by a former British prime minister. See here https://www.independent.co.uk/news/uk/politics/boris-johnson-colonialism-africa-british-empire-slavery-a9564541.html . This is why they work so hard to maintain colonial entanglements despite being thousands of kilometers away.
Points
of activity in a cascade
A
good example to help understand “important points of activity” in a cascade
process is the process of blood-clotting. This process is termed “coagulation
cascade” in medical jargon.
The
coagulation cascade, or secondary hemostasis, is a series of steps in response
to bleeding caused by tissue injury, where each step activates the next and
ultimately produces a blood clot. The term hemostasis is derived from “hem-”,
which means “blood”, and “-stasis”, which means “to stop.” Therefore,
hemostasis means to stop bleeding. There are two phases of hemostasis. First,
primary hemostasis forms an unstable platelet plug at the site of injury. Then,
the coagulation cascade is activated to stabilize the plug, stopping blood flow
and allowing increased time to make necessary repairs. This process minimizes
blood loss after injuries.
The
coagulation cascade involves the activation of a series of clotting factors,
which are proteins that are involved in blood clotting. Each clotting factor is
a serine protease, an enzyme that speeds up the breakdown of another protein.
The clotting factors are initially in an inactive form called zymogens. When
placed with its glycoprotein co-factor, the clotting factor is activated and is
then able to catalyze the next reaction. When a clotting factor becomes
activated, it is denoted with an “a” following its respective Roman numeral
(e.g. when activated, Factor V becomes Factor Va).
The
intrinsic factors&pathway means the factors and pathway initiated in the
blood while the extrinsic factors&pathway means the factors and pathway
initiated in the tissue. The two pathways merge into one common pathway, facilitated
by a reaction with calcium ions, at the end of which, a stable fibrin clot is
formed. The points of binding with calcium ions have been circled in red
because they are important points of activity that make the whole process a
success as well as maintaining the outcome to gradual “permanence”. Calcium
ions (Ca2+) play a major role in the tight regulation of coagulation
cascade that is paramount in the maintenance of hemostasis. Other than platelet
activation, calcium ions are responsible for complete activation of several
coagulation factors, including coagulation Factor XIII (FXIII). FXIII is
responsible for covalently cross-linking preformed fibrin clots preventing
their premature fibrinolysis, by maintaining the clot architecture and
strength.
The
Calcium ions (Ca2+) in all their calcium-binding sites with the various
zymogens generally work by crystallizing the structure of the zymogens – a process
termed “activation”. Nevertheless, there are additional regulatory/functional
features in the different activation mechanisms of different zymogens in the cascade
process. Replicating this process artificially is therefore more complex and
requires enormous amounts of data to create a framework/algorithm that can work
at least satisfactorily.
Calcium
in blood clotting and quantum computing
A
central idea in quantum mechanics is the idea of “quantum entanglement” of
particles. This is the idea that two particles may inherently share certain
similar physical properties like spin direction or electrical charge despite
the distance between them. And that these two particles influence each other in
case of any alteration without any medium of communication. Just like in the
era of alchemy which preceded chemistry, a lot of superstitious lingo has been
used to try to explain this idea, such as, “hidden variables”, “spooky action”,
“collapse of state from observation” and so forth.
The
experiments utilized to measure “quantum entanglement” are generally termed “bell
experiments”. The first bell experiment was performed by Stuart J. Freedman and
John Clauser using Freedman's inequality theorem – a variation of Bell’s CH74
inequality which theorized “hidden variables”. The association of these bell tests
with blood clotting in the title is due to the curious choice of radioactive calcium
ions to initiate a cascade process. Two photons emitted from the radiative
calcium are projected in different directions then measured at both ends. The
electrical charge measured at each end may be + or – at any given time. The
intrigue lies in simultaneous measurement of both ends which has been recorded as
being any combination, like ++, +-, -+, --. This is different from the currently
usual electrical connection whereby if one end is + charge, the other end will
be – charge to complete the circuit.
Conclusion
The
race for “quantum supremacy” between various Eurasian civilizations currently
permeates many fields of science and even humanities with a lot of hype, propaganda, false equivalences, false starts and false alarms. The desire to use “quantum” frameworks/models
for political and social purposes places even more pressure on its protagonists
in a fast-changing geo-political environment.
References
Retrieved from https://www.osmosis.org/answers/coagulation-cascade
13th Aug 2023
S.J. Freedman; J.F. Clauser
(1972). "Experimental test of local hidden-variable theories". Phys.
Rev. Lett. 28 (938): 938–941.
Singh, S., Dodt, J., Volkers,
P. et al. (2019). Structure functional insights into calcium binding during the
activation of coagulation factor XIII A. Sci Rep 9, 11324
TUKI (2001), Kamusi Ya
Kiswahili-Kiingereza; Swahili-English Dictionary. Published by Taasisi ya
Uchunguzi wa Kiswahili (TUKI), Chuo Kikuu cha Dar es Salaam, Tanzania.
Young, J.K., Gasior, S.L.,
Jones, S. et al. (2019). The repurposing of type I-E CRISPR-Cascade for gene
activation in plants. Commun Biol 2, 383
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